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Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis.


ABSTRACT: BACKGROUND/OBJECTIVES:Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B. SUBJECTS/METHODS:Eighty overweight participants were randomized (52 completed) to a 500?kcal/d energy deficit diet with a macronutrient composition of 30 energy percentage (E%) fat, 52 E% carbohydrate and 18 E% protein either high (?1500?mg calcium/day) or low (???600?mg calcium/day) in dairy products for 24 weeks. Body weight, body fat, and dietary intake (by 7-day dietary records) were determined. Individuals were dichotomized according to their pre-treatment P/B ratio derived from 16S rRNA gene sequencing of collected fecal samples to test the potential modification of dietary effects using linear mixed models. RESULTS:Independent of the randomized diets, individuals with high P/B lost 3.8?kg (95%CI, 1.8,5.8; P?

SUBMITTER: Hjorth MF 

PROVIDER: S-EPMC6331389 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis.

Hjorth Mads F MF   Blædel Trine T   Bendtsen Line Q LQ   Lorenzen Janne K JK   Holm Jacob B JB   Kiilerich Pia P   Roager Henrik M HM   Kristiansen Karsten K   Larsen Lesli H LH   Astrup Arne A  

International journal of obesity (2005) 20180517 1


<h4>Background/objectives</h4>Individuals with high pre-treatment bacterial Prevotella-to-Bacteroides (P/B) ratio have been reported to lose more body weight on diets high in fiber than subjects with a low P/B ratio. Therefore, the aim of the present study was to examine potential differences in dietary weight loss responses between participants with low and high P/B.<h4>Subjects/methods</h4>Eighty overweight participants were randomized (52 completed) to a 500 kcal/d energy deficit diet with a  ...[more]

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