Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.
Ontology highlight
ABSTRACT: Aim
Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.Materials & methods
We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium.Results
Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098).Conclusion
PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.
SUBMITTER: Uddin M
PROVIDER: S-EPMC6331697 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.
Uddin Monica M Ratanatharathorn Andrew A Armstrong Don D Kuan Pei-Fen PF Aiello Allison E AE Bromet Evelyn J EJ Galea Sandro S Koenen Karestan C KC Luft Benjamin B Ressler Kerry J KJ Wildman Derek E DE Nievergelt Caroline M CM Smith Alicia A
Epigenomics 20181120 12
<h4>Aim</h4>Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.<h4>Materials & methods</h4>We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts partic ...[more]
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