Dataset Information

Heart-to-Brachium Pulse Wave Velocity as a Measure of Proximal Aortic Stiffness: MRI and Longitudinal Studies.

ABSTRACT:

Background

Stiffening of the proximal aorta is associated with heightened cardiovascular disease risks but can be quantified by limited methodologies (e.g., magnetic resonance imaging [MRI]). As an initial step to evaluate the emerging technique to assess proximal aortic stiffness via pulse wave velocity from the heart to the brachium (hbPWV), we determined the influences of aging on pulse wave velocity (PWV) and aortic hemodynamics.

Method

Using the cross-sectional and follow-up study designs, hbPWV was compared and evaluated in relation to other PWV in various arterial segments. Arterial path lengths were measured by the 3-dimensional arterial tracing of MRI.

Results

In the cross-sectional study including 190 subjects (aged 19-79 years), hbPWV exhibited one of the largest age-related increases and a stronger correlation with age (r = 0.790) compared with the other measures of PWV including carotid-femoral PWV, brachial-ankle PWV, and PWV of muscular arteries (r = 0.445-0.688). In addition, hbPWV was correlated with aortic systolic blood pressure (BP) and augmentation index (r = 0.380 and 0.433, respectively) after controlling for brachial systolic BP. These results were confirmed by the 10-year follow-up study involving 84 individuals (53 years at baseline). The decadal changes in hbPWV were significantly correlated with the corresponding changes in several aortic hemodynamic variables (e.g., aortic systolic BP, augmentation pressure, and augmentation index) (r = 0.240-0.349).

Conclusions

The present findings indicate that hbPWV is a potential marker of proximal aortic stiffening that reflects age-related changes and aortic hemodynamics.

SUBMITTER: Sugawara J

PROVIDER: S-EPMC6331710 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Heart-to-Brachium Pulse Wave Velocity as a Measure of Proximal Aortic Stiffness: MRI and Longitudinal Studies.

Sugawara Jun J Tomoto Tsubasa T Tanaka Hirofumi H

American journal of hypertension 20190101 2

<h4>Background</h4>Stiffening of the proximal aorta is associated with heightened cardiovascular disease risks but can be quantified by limited methodologies (e.g., magnetic resonance imaging [MRI]). As an initial step to evaluate the emerging technique to assess proximal aortic stiffness via pulse wave velocity from the heart to the brachium (hbPWV), we determined the influences of aging on pulse wave velocity (PWV) and aortic hemodynamics.<h4>Method</h4>Using the cross-sectional and follow-up ...[more]

PMID: 30445561

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Project description:PurposeTo assess intraobserver, interobserver, and scan-rescan variability of MRI aortic stiffness measurements in a multicenter trial setting.Materials and methodsThis study was a retrospective analysis of prospectively collected data in a multicenter prospective clinical trial (clinicaltrials.gov ID NCT01870739). Forty-five adult patients (31 men; mean age, 58 years ± 12 [standard deviation]; 15 patients per center; three centers) with arterial hypertension underwent standardized 3-T baseline MRI assessments between June and September 2014. Aortic strain was calculated from maximum and minimum aortic area measurements repeated three times by three readers at three aortic levels on three retrospectively gated axial gradient-echo (GRE) data sets. Pulse wave velocity (PWV) was assessed three times by five readers as Δx/Δt: Δx was measured on a parasagittal GRE image of the aortic arch, and Δt was extracted from ascending and descending aortic velocity curves created on three axial phase-contrast acquisitions. Intraobserver, interobserver, and scan-rescan variability was calculated using percentage coefficient of variation (COV).ResultsAortic strain variability was lowest at the level of the distal descending aorta (DDA) with median COVs of 1.6% for intraobserver variability, 4.0% for interobserver variability, and 10.3% for scan-rescan variability. It was highest at the ascending aorta (AA) with COVs of 3.6% for intraobserver variability, 10.7% for interobserver variability, and 19.8% for scan-rescan variability. Variability of PWV was low: 0.7% for intraobserver variability, 1.5% for interobserver variability, and 8.1% for scan-rescan variability.ConclusionLow variability can be achieved for aortic strain and PWV measurements in a multicenter trial setting using standardized MRI protocols. Although COV was lower when measuring aortic strain at DDA compared with AA, variability was acceptable at both anatomic locations.Supplemental material is available for this article.© RSNA, 2020.

Dataset Information

Heart-to-Brachium Pulse Wave Velocity as a Measure of Proximal Aortic Stiffness: MRI and Longitudinal Studies.

Background

Method

Results

Conclusions

Publications

Heart-to-Brachium Pulse Wave Velocity as a Measure of Proximal Aortic Stiffness: MRI and Longitudinal Studies.

Similar Datasets

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