Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.
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ABSTRACT:
SUBMITTER: Mancuso G
PROVIDER: S-EPMC6331789 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.
Mancuso Giuseppe G Borgonovo Gigliola G Scaglioni Leonardo L Bassoli Angela A
Molecules (Basel, Switzerland) 20151016 10
Ruta graveolens (rue) is a spontaneous plant in the Mediterranean area with a strong aroma and a very intense bitter taste, used in gastronomy and in folk medicine. From the leaves, stems and fruits of rue, we isolated rutin, rutamarin, three furanocoumarins, two quinolinic alkaloids, a dicoumarin and two long chain ketones. Bitter taste and chemesthetic properties have been evaluated by in vitro assays with twenty receptors of the TAS2R family and four TRP ion channels involved in gustation and ...[more]
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