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A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa.

ABSTRACT: A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A-C (2-4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1-3 exhibited protective effects against DOX-induced cardiotoxicity.

SUBMITTER: Li M

PROVIDER: S-EPMC6332001 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa.

Li Meng M Wang Xiaolan X Zheng Xiaoke X Wang Jianchao J Zhao Wei W Song Kai K Zhao Xuan X Zhang Yanli Y Kuang Haixue H Feng Weisheng W

Molecules (Basel, Switzerland) 20150820 8

A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A-C (2-4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1-3 exhibited protective effects against DOX-induced cardiotoxicity. ...[more]

PMID: 26307955

Dataset Information

A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa.

Publications

A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa.

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