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Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract.

ABSTRACT: Through dereplication analysis, seven known Mammea coumarins were identified in a fraction obtained from Mammea neurophylla dichloromethane bark extract selected for its ability to prevent advanced glycation end-product (AGE) formation. Among them, a careful examination of the NMR dataset of pedilanthocoumarin B led to a structural revision. Inspection of LC-DAD-MS(n) chromatograms allowed us to predict the presence of four new compounds, which were further isolated. Using spectroscopic methods (¹H-, (13)C- and 2D-NMR, HRMS, UV), these compounds were identified as new benzoyl substituted 4-phenylcoumarins (iso-pedilanthocoumarin B and neurophyllol C) and 4-(1-acetoxypropyl)coumarins cyclo F (ochrocarpins H and I).

SUBMITTER: Dang BT

PROVIDER: S-EPMC6332034 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract.

Dang Bach Tai BT Rouger Caroline C Litaudon Marc M Richomme Pascal P Séraphin Denis D Derbré Séverine S

Molecules (Basel, Switzerland) 20150925 10

Through dereplication analysis, seven known Mammea coumarins were identified in a fraction obtained from Mammea neurophylla dichloromethane bark extract selected for its ability to prevent advanced glycation end-product (AGE) formation. Among them, a careful examination of the NMR dataset of pedilanthocoumarin B led to a structural revision. Inspection of LC-DAD-MS(n) chromatograms allowed us to predict the presence of four new compounds, which were further isolated. Using spectroscopic methods ...[more]

PMID: 26404214

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Dataset Information

Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract.

Publications

Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract.

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