Ontology highlight
ABSTRACT:
SUBMITTER: van Duijnhoven SM
PROVIDER: S-EPMC6332093 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20150702 7
Membrane type-1 matrix metalloproteinase (MT1-MMP or MMP-14) plays an important role in adverse cardiac remodelling. Here, we aimed to develop radiolabeled activatable cell penetrating peptides (ACPP) sensitive to MT1-MMP for the detection of elevated MT1-MMP levels in adverse cardiac remodelling. Three ACPP analogs were synthesized and the most potent ACPP analog was selected using MT1-MMP sensitivity and enzyme specificity assays. This ACPP, called ACPP-B, showed high sensitivity towards MT1-M ...[more]