Ontology highlight
ABSTRACT:
SUBMITTER: Cai D
PROVIDER: S-EPMC6332143 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Cai Dong D Zhang Zhi-Hua ZH Chen Yu Y Yan Xin-Jia XJ Zou Liang-Jing LJ Wang Ya-Xin YX Liu Xue-Qi XQ
Molecules (Basel, Switzerland) 20150910 9
A series of 5H-thiazolo[3,2-a]pyrimidin-5-ones were synthesized by the cyclization reactions of S-alkylated derivatives in concentrated H₂SO₄. Upon treatment of S-alkylated derivatives at different temperatures, intramolecular cyclization to 7-(substituted phenylamino)-5H-thiazolo[3,2-a]pyrimidin-5-ones or sulfonation of cyclized products to sulfonic acid derivatives occurred. The structures of the target compounds were confirmed by IR, ¹H-NMR, (13)C-NMR and HRMS studies. The compounds were eval ...[more]