Dichlorinated and Brominated Rugulovasines, Ergot Alkaloids Produced by Talaromyces wortmannii.
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ABSTRACT:
SUBMITTER: de Medeiros LS
PROVIDER: S-EPMC6332237 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
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Dichlorinated and Brominated Rugulovasines, Ergot Alkaloids Produced by Talaromyces wortmannii.
de Medeiros Lívia Soman LS da Silva José Vinícius JV Abreu Lucas Magalhães LM Pfenning Ludwig Heinrich LH Silva Carolina Lúcia CL Thomasi Sérgio Secherrer SS Venâncio Tiago T van Pée Karl-Heinz KH Nielsen Kristian Fog KF Rodrigues-Filho Edson E
Molecules (Basel, Switzerland) 20150923 9
UHPLC-DAD-HRMS based dereplication guided the detection of new halogenated alkaloids co-produced by Talaromyces wortmannii. From the fungal growth in large scale, the epimers 2,8-dichlororugulovasines A and B were purified and further identified by means of a HPLC-SPE/NMR hyphenated system. Brominated rugulovasines were also detected when the microbial incubation medium was supplemented with bromine sources. Studies from 1D/2D NMR and HRMS spectroscopy data allowed the structural elucidation of ...[more]
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