Ontology highlight
ABSTRACT:
SUBMITTER: Mattarei A
PROVIDER: S-EPMC6332312 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20150903 9
Resveratrol is a natural polyphenol with many interesting biological activities. Its pharmacological exploitation in vivo is, however, hindered by its rapid elimination via phase II conjugative metabolism at the intestinal and, most importantly, hepatic levels. One approach to bypass this problem relies on prodrugs. We report here the synthesis, characterization, hydrolysis, and in vivo pharmacokinetic behavior of resveratrol prodrugs in which the OH groups are engaged in an N-monosubstituted ca ...[more]