Ontology highlight
ABSTRACT:
SUBMITTER: Zu M
PROVIDER: S-EPMC6332427 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Zu Mian M Li Chao C Fang Jian-Song JS Lian Wen-Wen WW Liu Ai-Lin AL Zheng Li-Shu LS Du Guan-Hua GH
Molecules (Basel, Switzerland) 20151102 11
The rapid evolution of influenza virus makes antiviral drugs less effective, which is considered to be a major bottleneck in antiviral therapy. The key proteins in the host cells, which are related with the replication cycle of influenza virus, are regarded as potential drug targets due to their distinct advantage of lack of evolution and drug resistance. Cdc2-like kinase 1 (CLK1) in the host cells is responsible for alternative splicing of the M2 gene of influenza virus during influenza infecti ...[more]