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Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl.

ABSTRACT: An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.

SUBMITTER: Chen WC

PROVIDER: S-EPMC6332431 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl.

Chen Wen-Chang WC Lin Chan-Chieh CC Kavala Veerababurao V Kuo Chun-Wei CW Huang Chia-Yu CY Yao Ching-Fa CF

Molecules (Basel, Switzerland) 20151215 12

An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high. ...[more]

PMID: 26694335

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