Multi-omics integration reveals molecular networks and regulators of psoriasis.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC6332659 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Multi-omics integration reveals molecular networks and regulators of psoriasis.
Zhao Yuqi Y Jhamb Deepali D Shu Le L Arneson Douglas D Rajpal Deepak K DK Yang Xia X
BMC systems biology 20190114 1
<h4>Background</h4>Psoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic and epigenetic variants that are associated with psoriasis. However, these loci cannot fully explain the disease pathogenesis.<h4>Methods</h4>To achieve a comprehensive mechanistic understanding of psoriasis, we conducted a systems biolog ...[more]
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