Emerging Therapies for Spastic Movement Disorders.
Ontology highlight
ABSTRACT:
SUBMITTER: Raghavan P
PROVIDER: S-EPMC6333099 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Emerging Therapies for Spastic Movement Disorders.
Physical medicine and rehabilitation clinics of North America 20180602 3
Spasticity develops as a result of central nervous system (CNS) injury; however, secondary changes within the muscles and connective tissue also contribute to muscle stiffness. The hyaluronan hypothesis postulates that the accumulation of hyaluronan promotes the development of muscle stiffness. Intramuscular injections of the enzyme hyaluronidase, which hydrolyzes long-chained hyaluronan polymers to smaller polymers, was shown to reduce muscle stiffness and increase passive and active range of m ...[more]
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