Ontology highlight
ABSTRACT:
SUBMITTER: Lu HH
PROVIDER: S-EPMC6333234 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Lu Hung-Hsun HH Huang Cheng-Hung CH Shiue Ting-Yun TY Wang Fu-Sheng FS Chang Ko-Kai KK Chen Yunching Y Peng Chi-How CH
Chemical science 20181004 1
Triblock copolymer of poly(ethylene glycol)-<i>b</i>-poly(2-dimethylaminoethyl methacrylate)-<i>b</i>-poly(pyrenylmethyl methacrylate) (PEG-<i>b</i>-PDMAEMA-<i>b</i>-PPy) has been developed for use as an ideal gene delivery system, which showed both high stability under physiological conditions and efficient gene release in a mimetic cancer environment. The siRNA release from this system without external stimulation was 16% in 1 h and then remained steady. However, the photo-triggered siRNA rele ...[more]