An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration.
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ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC6333278 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
An immunological electrospun scaffold for tumor cell killing and healthy tissue regeneration.
Liu Xingzhi X Zhang Hongbo H Cheng Ruoyu R Gu Yanzheng Y Yin Yin Y Sun Zhiyong Z Pan Guoqing G Deng Zhongbin Z Yang Huilin H Deng Lianfu L Cui Wenguo W Santos Hélder A HA Shi Qin Q
Materials horizons 20180816 6
Antibody-based cancer immune therapy has attracted lots of research interest in recent years; however, it is greatly limited by the easy distribution and burst release of antibodies. In addition, after the clearance of the tissue, healthy tissue regeneration is another challenge for cancer treatment. Herein, we have developed a specific immunological tissue engineering scaffold using the agonistic mouse anti-human CD40 antibody (CD40mAb) incorporated into poly(l-lactide) (PLLA) electrospun fiber ...[more]
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