Ontology highlight
ABSTRACT:
SUBMITTER: Mezzadra R
PROVIDER: S-EPMC6333292 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Mezzadra Riccardo R Sun Chong C Jae Lucas T LT Gomez-Eerland Raquel R de Vries Evert E Wu Wei W Logtenberg Meike E W MEW Slagter Maarten M Rozeman Elisa A EA Hofland Ingrid I Broeks Annegien A Horlings Hugo M HM Wessels Lodewyk F A LFA Blank Christian U CU Xiao Yanling Y Heck Albert J R AJR Borst Jannie J Brummelkamp Thijn R TR Schumacher Ton N M TNM
Nature 20170816 7670
The clinical benefit for patients with diverse types of metastatic cancers that has been observed upon blockade of the interaction between PD-1 and PD-L1 has highlighted the importance of this inhibitory axis in the suppression of tumour-specific T-cell responses. Notwithstanding the key role of PD-L1 expression by cells within the tumour micro-environment, our understanding of the regulation of the PD-L1 protein is limited. Here we identify, using a haploid genetic screen, CMTM6, a type-3 trans ...[more]