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Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics.


ABSTRACT: Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.

SUBMITTER: Keppler EAH 

PROVIDER: S-EPMC6333419 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics.

Keppler Emily A Higgins EAH   Jenkins Carrie L CL   Davis Trenton J TJ   Bean Heather D HD  

Trends in analytical chemistry : TRAC 20181024


Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data. ...[more]

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