Ontology highlight
ABSTRACT:
SUBMITTER: Xia Y
PROVIDER: S-EPMC6333734 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Xia Yimeng Y Sun Xiaoyun X Luo Yan Y Stary Creed M CM
Frontiers in molecular neuroscience 20190109
The underlying mechanisms of isoflurane neurotoxicity in the developing brain remain unclear. Ferroptosis is a recently characterized form of programmed cell death distinct from apoptosis or autophagy, characterized by iron-dependent reactive oxygen species (ROS) generation secondary to failure of glutathione-dependent antioxidant defenses. The results of the present study are the first to demonstrate <i>in vitro</i> that ferroptosis is a central mechanism contributing to isoflurane neurotoxicit ...[more]