Ontology highlight
ABSTRACT:
SUBMITTER: Askoxylakis V
PROVIDER: S-EPMC6333771 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Askoxylakis Vasileios V Ferraro Gino B GB Badeaux Mark M Kodack David P DP Kirst Isabelle I Shankaraiah Ram C RC Wong Christina S F CSF Duda Dan G DG Fukumura Dai D Jain Rakesh K RK
NPJ breast cancer 20190115
The effective treatment of cerebral metastases from HER2-positive breast cancer remains an unmet need. Recent studies indicate that activated astrocytes and brain endothelial cells exert chemoprotective effects on cancer cells through direct physical interaction. Here we report that the endothelin axis mediates protection of <i>HER2</i>-amplified brain metastatic breast cancers to the anti-HER2 antibody-drug conjugate ado-trastuzumab emtansine (T-DM1). Macitentan, a dual inhibitor of endothelin ...[more]