Ontology highlight
ABSTRACT:
SUBMITTER: Huynh F
PROVIDER: S-EPMC6334173 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20180716 17
Terpene synthases catalyse the first step in the conversion of prenyl diphosphates to terpenoids. They act as templates for their substrates to generate a reactive conformation, from which a Mg<sup>2+</sup> -dependent reaction creates a carbocation-PP<sub>i</sub> ion pair that undergoes a series of rearrangements and (de)protonations to give the final terpene product. This tight conformational control was exploited for the (R)-germacrene A synthase- and germacradien-4-ol synthase-catalysed forma ...[more]