Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Muse T
PROVIDER: S-EPMC6334227 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Garcia-Muse Tatiana T Galindo-Diaz U U Garcia-Rubio M M Martin J S JS Polanowska J J O'Reilly N N Aguilera A A Boulton Simon J SJ
Cell reports 20190101 3
Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, but how meiotic cells are protected from unscheduled DNA breaks remains unexplored. Here we define a checkpoint response to persistent meiotic DSBs in C. elegans that phosphorylates the synaptonemal complex (SC) to switch repair partner from the homolog to the sister chromatid ...[more]