Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.
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ABSTRACT:
SUBMITTER: Dong X
PROVIDER: S-EPMC6334654 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease.
Dong Xianjun X Liao Zhixiang Z Gritsch David D Hadzhiev Yavor Y Bai Yunfei Y Locascio Joseph J JJ Guennewig Boris B Liu Ganqiang G Blauwendraat Cornelis C Wang Tao T Adler Charles H CH Hedreen John C JC Faull Richard L M RLM Frosch Matthew P MP Nelson Peter T PT Rizzu Patrizia P Cooper Antony A AA Heutink Peter P Beach Thomas G TG Mattick John S JS Müller Ferenc F Scherzer Clemens R CR
Nature neuroscience 20180917 10
Enhancers function as DNA logic gates and may control specialized functions of billions of neurons. Here we show a tailored program of noncoding genome elements active in situ in physiologically distinct dopamine neurons of the human brain. We found 71,022 transcribed noncoding elements, many of which were consistent with active enhancers and with regulatory mechanisms in zebrafish and mouse brains. Genetic variants associated with schizophrenia, addiction, and Parkinson's disease were enriched ...[more]
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