Ontology highlight
ABSTRACT:
SUBMITTER: Battistini MR
PROVIDER: S-EPMC6334763 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Battistini Matthew R MR O'Flynn Brian G BG Shoji Christopher C Suarez Gabriela G Galloway Lamar C LC Merkler David J DJ
Archives of biochemistry and biophysics 20181116
The arylalkylamine N-acyltransferases (AANATs) are enzymes that catalyze the acyl-CoA-dependent formation of N-acylarylalkylamides: acyl-CoA + arylalkylamine → N-acylarylalkylamides + CoA-SH. Herein, we describe our study of a previously uncharacterized AANAT from Bombyx mori: Bm-iAANAT3. Bm-iAANAT3 catalyzes the direct formation of N-acylarylalkylamides and accepts a broad range of short-chain acyl-CoA thioesters and amines as substrates. Acyl-CoA thioesters possessing an acyl chain length >10 ...[more]