Ontology highlight
ABSTRACT:
SUBMITTER: Caswell-Jin JL
PROVIDER: S-EPMC6335111 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Caswell-Jin Jennifer L JL Zimmer Anjali D AD Stedden Will W Kingham Kerry E KE Zhou Alicia Y AY Kurian Allison W AW
Journal of the National Cancer Institute 20190101 1
In cascade testing, genetic testing for an identified familial pathogenic variant extends to disease-free relatives to allow genetically targeted disease prevention. We evaluated the results of an online initiative in which carriers of 1 of 30 cancer-associated genes, or their first-degree relatives, could offer low-cost testing to at-risk first-degree relatives. In the first year, 1101 applicants invited 2280 first-degree relatives to undergo genetic testing. Of invited relatives, 47.5% (95% co ...[more]