Ontology highlight
ABSTRACT:
SUBMITTER: Hooks JST
PROVIDER: S-EPMC6335159 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Hooks Joshua S T JST Clement Cristina C CC Nguyen Hoang-Dung HD Santambrogio Laura L Dixon J Brandon JB
Microcirculation (New York, N.Y. : 1994) 20181129 1
<h4>Objective</h4>Using primary LMCs in vitro, we sought to characterize the impact of LMC remodeling on their functional and molecular response to mechanical loading and culture conditions.<h4>Methods</h4>Primary "wounded leg" LMCs were derived from the hindlimb of three sheep who underwent lymphatic injury 6 weeks prior, while "control leg" LMCs were derived from the contralateral, unwounded, limb. Function of the LMCs was characterized in response to media of variable levels of serum (10% vs ...[more]