Ontology highlight
ABSTRACT:
SUBMITTER: Piedra-Quintero ZL
PROVIDER: S-EPMC6335276 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Piedra-Quintero Zayda L ZL Serrano Carolina C Villegas-Sepúlveda Nicolás N Maravillas-Montero José L JL Romero-Ramírez Sandra S Shibayama Mineko M Medina-Contreras Oscar O Nava Porfirio P Santos-Argumedo Leopoldo L
Frontiers in immunology 20190110
Intestinal macrophages are highly mobile cells with extraordinary plasticity and actively contribute to cytokine-mediated epithelial cell damage. The mechanisms triggering macrophage polarization into a proinflammatory phenotype are unknown. Here, we report that during inflammation macrophages enhance its intercellular adhesion properties in order to acquire a M1-phenotype. Using <i>in vitro</i> and <i>in vivo</i> models we demonstrate that intercellular adhesion is mediated by integrin-αVβ3 and ...[more]