Ontology highlight
ABSTRACT:
SUBMITTER: Belur Nagaraj A
PROVIDER: S-EPMC6335585 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Belur Nagaraj Anil A Joseph Peronne P Ponting Erin E Fedorov Yuriy Y Singh Salendra S Cole Alex A Lee Woncheol W Yoon Euisik E Baccarini Alessia A Scacheri Peter P Buckanovich Ronald R Adams Drew J DJ Drapkin Ronny R Brown Brian D BD DiFeo Analisa A
Stem cell reports 20190101 1
Tumor-initiating cells (TICs) contribute to drug resistance and tumor recurrence in cancers, thus experimental approaches to dissect the complexity of TICs are required to design successful TIC therapeutic strategies. Here, we show that miRNA-3' UTR sensor vectors can be used as a pathway-based method to identify, enrich, and analyze TICs from primary solid tumor patient samples. We have found that an miR-181a<sup>high</sup> subpopulation of cells sorted from primary ovarian tumor cells exhibite ...[more]