Ontology highlight
ABSTRACT:
SUBMITTER: Kurtulus S
PROVIDER: S-EPMC6336113 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Kurtulus Sema S Madi Asaf A Escobar Giulia G Klapholz Max M Nyman Jackson J Christian Elena E Pawlak Mathias M Dionne Danielle D Xia Junrong J Rozenblatt-Rosen Orit O Kuchroo Vijay K VK Regev Aviv A Anderson Ana C AC
Immunity 20190108 1
An improved understanding of the anti-tumor CD8<sup>+</sup> T cell response after checkpoint blockade would enable more informed and effective therapeutic strategies. Here we examined the dynamics of the effector response of CD8<sup>+</sup> tumor-infiltrating lymphocytes (TILs) after checkpoint blockade therapy. Bulk and single-cell RNA profiles of CD8<sup>+</sup> TILs after combined Tim-3+PD-1 blockade in preclinical models revealed significant changes in the transcriptional profile of PD-1<sup ...[more]