SNW1, a Novel Transcriptional Regulator of the NF-?B Pathway.
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ABSTRACT:
SUBMITTER: Verma S
PROVIDER: S-EPMC6336138 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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SNW1, a Novel Transcriptional Regulator of the NF-κB Pathway.
Verma Suneer S De Jesus Paul P Chanda Sumit K SK Verma Inder M IM
Molecular and cellular biology 20190116 3
The nuclear factor kappa B (NF-κB) family of transcription factors plays a central role in coordinating the expression of genes that control inflammation, immune responses, cell proliferation, and a variety of other biological processes. In an attempt to identify novel regulators of this pathway, we performed whole-genome RNA interference (RNAi) screens in physiologically relevant human macrophages in response to lipopolysaccharide and tumor necrosis factor alpha (TNF-α). The top hit was SNW1, a ...[more]
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