Ontology highlight
ABSTRACT:
SUBMITTER: Lu YC
PROVIDER: S-EPMC6336197 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Lu Yi-Chien YC Sanada Chad C Xavier-Ferrucio Juliana J Wang Lin L Zhang Ping-Xia PX Grimes H Leighton HL Venkatasubramanian Meenakshi M Chetal Kashish K Aronow Bruce B Salomonis Nathan N Krause Diane S DS
Cell reports 20181101 8
Megakaryocytic-erythroid progenitors (MEPs) give rise to the cells that produce red blood cells and platelets. Although the mechanisms underlying megakaryocytic (MK) and erythroid (E) maturation have been described, those controlling their specification from MEPs are unknown. Single-cell RNA sequencing of primary human MEPs, common myeloid progenitors (CMPs), megakaryocyte progenitors, and E progenitors revealed a distinct transitional MEP signature. Inferred regulatory transcription factors (TF ...[more]