Ontology highlight
ABSTRACT:
SUBMITTER: Pilch Z
PROVIDER: S-EPMC6336379 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
PloS one 20190117 1
Tumor-infiltrating immune cells can impact tumor growth and progression. The inhibitory CD200 receptor (CD200R) suppresses the activation of myeloid cells and lack of this pathway results in a reduction of tumor growth, conversely a tumorigenic effect of CD200R triggering was also described. Here we investigated the role of CD200R activation in syngeneic mouse tumor models. We showed that agonistic CD200R antibody reached tumors, but had no significant impact on tumor growth and minor effect on ...[more]