Ontology highlight
ABSTRACT:
SUBMITTER: Marcinkiewicz AL
PROVIDER: S-EPMC6336514 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Marcinkiewicz Ashley L AL Dupuis Alan P AP Zamba-Campero Maxime M Nowak Nancy N Kraiczy Peter P Ram Sanjay S Kramer Laura D LD Lin Yi-Pin YP
Cellular microbiology 20190107 2
Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. The spirochetes are transmitted from mammalian and avian reservoir hosts to humans via ticks. Following tick bites, spirochetes colonize the host skin and then disseminate haematogenously to various organs, a process that requires this pathogen to evade host complement, an innate immune defence system. CspZ, a spirochete surface protein, facilitates resistance to ...[more]