Ontology highlight
ABSTRACT:
SUBMITTER: Groß A
PROVIDER: S-EPMC6336720 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Groß Alexander A Kracher Barbara B Kraus Johann M JM Kühlwein Silke D SD Pfister Astrid S AS Wiese Sebastian S Luckert Katrin K Pötz Oliver O Joos Thomas T Van Daele Dries D De Raedt Luc L Kühl Michael M Kestler Hans A HA
Communications biology 20190117
Dynamic models analyzing gene regulation and metabolism face challenges when adapted to modeling signal transduction networks. During signal transduction, molecular reactions and mechanisms occur in different spatial and temporal frames and involve feedbacks. This impedes the straight-forward use of methods based on Boolean networks, Bayesian approaches, and differential equations. We propose a new approach, ProbRules, that combines probabilities and logical rules to represent the dynamics of a ...[more]