The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers.
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SUBMITTER: Kaiser M
PROVIDER: S-EPMC6337111 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
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The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers.
Kaiser Mathias M Burek Malgorzata M Britz Stefan S Lankamp Frauke F Ketelhut Steffi S Kemper Björn B Förster Carola C Gorzelanny Christian C Goycoolea Francisco M FM
International journal of molecular sciences 20181230 1
Microvascular endothelial cells are an essential part of many biological barriers, such as the blood⁻brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine en ...[more]
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