Ontology highlight
ABSTRACT:
SUBMITTER: Labyb M
PROVIDER: S-EPMC6337181 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Labyb Mehdi M Chrétien Chloé C Caillon Aurélie A Rohner-Jeanrenaud Françoise F Altirriba Jordi J
International journal of molecular sciences 20181226 1
Whereas leptin administration only has a negligible effect on the treatment of obesity, it has been demonstrated that its action can be improved by co-administration of leptin and one of its sensitizers. Considering that oxytocin treatment decreases body weight in obese animals and humans, we investigated the effects of oxytocin and leptin cotreatment. First, lean and diet-induced obese (DIO) mice were treated with oxytocin for 2 weeks and we measured the acute leptin response. Second, DIO mice ...[more]