Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer.
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ABSTRACT:
SUBMITTER: Keijzers G
PROVIDER: S-EPMC6337416 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer.
Keijzers Guido G Bakula Daniela D Petr Michael Angelo MA Madsen Nils Gedsig Kirkelund NGK Teklu Amanuel A Mkrtchyan Garik G Osborne Brenna B Scheibye-Knudsen Morten M
International journal of molecular sciences 20181225 1
Human exonuclease 1 (EXO1), a 5'→3' exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In thi ...[more]
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