Zhile Capsule Exerts Antidepressant-Like Effects through Upregulation of the BDNF Signaling Pathway and Neuroprotection.
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ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC6337550 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
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Zhile Capsule Exerts Antidepressant-Like Effects through Upregulation of the BDNF Signaling Pathway and Neuroprotection.
Wu Jiawei J Zhang Tingting T Yu Luping L Huang Shuai S Yang Yu Y Yu Suyun S Li Jun J Cao Yuzhu Y Wei Zhonghong Z Li Xiaoman X Wu Yuanyuan Y Chen Wenxing W Wang Aiyun A Lu Yin Y
International journal of molecular sciences 20190108 1
Major depressive disorder is now becoming a common disease in daily life, and most patients do not have satisfactory treatment outcomes. We herein evaluated the therapeutic effects of Zhile capsule and clarified the molecular mechanism. A rat model of chronic unpredictable mild stress-induced depression was established to assess the antidepressant-like effects of Zhile by using the sucrose preference test, open field test, forced swim test, tail suspension test and HPLC. Systems pharmacology was ...[more]
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