Ontology highlight
ABSTRACT:
SUBMITTER: Urbanova K
PROVIDER: S-EPMC6337631 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Urbanová Kristína K Ramírez-Macías Inmaculada I Martín-Escolano Rubén R Rosales María José MJ Cussó Olaf O Serrano Joan J Company Anna A Sánchez-Moreno Manuel M Costas Miquel M Ribas Xavi X Marín Clotilde C
Molecules (Basel, Switzerland) 20181231 1
The spectrum and efficacy of available antileishmanial drugs is limited. In the present work we evaluated in vitro the antiproliferative activity of 11 compounds based on tetradentate polyamines compounds against three <i>Leishmania</i> species (<i>L. braziliensis</i>, <i>L. donovani</i> and <i>L. infantum</i>) and the possible mechanism of action. We identified six compounds (<b>3</b>, <b>5</b>, <b>6</b>, <b>7</b>, <b>8</b> and <b>10</b>) effective against all three <i>Leishmania</i> spp both o ...[more]