Ontology highlight
ABSTRACT:
SUBMITTER: Chiang TS
PROVIDER: S-EPMC6337904 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Chiang Tsai-Shin TS Lin Ming-Chieh MC Tsai Meng-Chen MC Chen Chieh-Hsin CH Jang Li-Ting LT Lee Fang-Jen S FS
Molecular biology of the cell 20181114 1
Cell migration is a highly regulated event that is initiated by cell membrane protrusion and actin reorganization. Robo1, a single-pass transmembrane receptor, is crucial for neuronal guidance and cell migration. ADP-ribosylation factor (Arf)-like 4A (Arl4A), an Arf small GTPase, functions in cell morphology, cell migration, and actin cytoskeleton remodeling; however, the molecular mechanisms of Arl4A in cell migration are unclear. Here, we report that the binding of Arl4A to Robo1 modulates cel ...[more]