Ontology highlight
ABSTRACT:
SUBMITTER: Kinehara Y
PROVIDER: S-EPMC6338389 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Kinehara Yuhei Y Nagatomo Izumi I Koyama Shohei S Ito Daisuke D Nojima Satoshi S Kurebayashi Ryota R Nakanishi Yoshimitsu Y Suga Yasuhiko Y Nishijima-Futami Yu Y Osa Akio A Nakatani Takeshi T Kato Yasuhiro Y Nishide Masayuki M Hayama Yoshitomo Y Higashiguchi Masayoshi M Morimura Osamu O Miyake Kotaro K Kang Sujin S Minami Toshiyuki T Hirata Haruhiko H Iwahori Kota K Takimoto Takayuki T Takamatsu Hyota H Takeda Yoshito Y Hosen Naoki N Hoshino Shigenori S Shintani Yasushi Y Okumura Meinoshin M Kumagai Toru T Nishino Kazumi K Imamura Fumio F Nakatsuka Shin-Ichi SI Kijima Takashi T Kida Hiroshi H Kumanogoh Atsushi A
JCI insight 20181220 24
Although responses to EGFR tyrosine kinase inhibitors (EGFR-TKIs) are initially positive, 30%-40% of patients with EGFR-mutant tumors do not respond well to EGFR-TKIs, and most lung cancer patients harboring EGFR mutations experience relapse with resistance. Therefore, it is necessary to identify not only the mechanisms underlying EGFR-TKI resistance, but also potentially novel therapeutic targets and/or predictive biomarkers for EGFR-mutant lung adenocarcinoma. We found that the GPI-anchored pr ...[more]