Dataset Information

Comparisons between the ON- and OFF-edge motion pathways in the Drosophila brain.

ABSTRACT: Understanding the circuit mechanisms behind motion detection is a long-standing question in visual neuroscience. In Drosophila melanogaster, recently discovered synapse-level connectomes in the optic lobe, particularly in ON-pathway (T4) receptive-field circuits, in concert with physiological studies, suggest a motion model that is increasingly intricate when compared with the ubiquitous Hassenstein-Reichardt model. By contrast, our knowledge of OFF-pathway (T5) has been incomplete. Here, we present a conclusive and comprehensive connectome that, for the first time, integrates detailed connectivity information for inputs to both the T4 and T5 pathways in a single EM dataset covering the entire optic lobe. With novel reconstruction methods using automated synapse prediction suited to such a large connectome, we successfully corroborate previous findings in the T4 pathway and comprehensively identify inputs and receptive fields for T5. Although the two pathways are probably evolutionarily linked and exhibit many similarities, we uncover interesting differences and interactions that may underlie their distinct functional properties.

SUBMITTER: Shinomiya K

PROVIDER: S-EPMC6338461 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Comparisons between the ON- and OFF-edge motion pathways in the <i>Drosophila</i> brain.

Shinomiya Kazunori K Huang Gary G Lu Zhiyuan Z Parag Toufiq T Xu C Shan CS Aniceto Roxanne R Ansari Namra N Cheatham Natasha N Lauchie Shirley S Neace Erika E Ogundeyi Omotara O Ordish Christopher C Peel David D Shinomiya Aya A Smith Claire C Takemura Satoko S Talebi Iris I Rivlin Patricia K PK Nern Aljoscha A Scheffer Louis K LK Plaza Stephen M SM Meinertzhagen Ian A IA

eLife 20190109

Understanding the circuit mechanisms behind motion detection is a long-standing question in visual neuroscience. In <i>Drosophila melanogaster</i>, recently discovered synapse-level connectomes in the optic lobe, particularly in ON-pathway (T4) receptive-field circuits, in concert with physiological studies, suggest a motion model that is increasingly intricate when compared with the ubiquitous Hassenstein-Reichardt model. By contrast, our knowledge of OFF-pathway (T5) has been incomplete. Here, ...[more]

PMID: 30624205

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Dataset Information

Comparisons between the ON- and OFF-edge motion pathways in the Drosophila brain.

Publications

Comparisons between the ON- and OFF-edge motion pathways in the <i>Drosophila</i> brain.

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