Ontology highlight
ABSTRACT:
SUBMITTER: Song HS
PROVIDER: S-EPMC6338755 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Song Hae Seong HS Song Young Ho YH Singh Nem N Kim Hyunuk H Jeon Hyelin H Kim Inhye I Kang Se Chan SC Chi Ki-Whan KW
Scientific reports 20190118 1
We report herein on the design, synthesis and biological activity of Ru-based self-assembled supramolecular bowls as a potent anticancer therapeutic in human hepatocellular cancer. The potent complex induces production of reactive oxygen species (ROS) by higher fatty acid β-oxidation and down-regulation of glucose transporter-mediated pyruvate dehydrogenase kinase 1 via reduced hypoxia-inducible factor 1α. Also, overexpressed acetyl-CoA activates the tricarboxylic acid cycle and the electron tra ...[more]