Ontology highlight
ABSTRACT:
SUBMITTER: Salahuddin S
PROVIDER: S-EPMC6338769 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Salahuddin Sadia S Fath Emma K EK Biel Natalie N Ray Ashley A Moss C Randall CR Patel Akash A Patel Sheetal S Hilding Leslie L Varn Matthew M Ross Tabithia T Cramblet Wyatt T WT Lowrey Angela A Pagano Joseph S JS Shackelford Julia J Bentz Gretchen L GL
Scientific reports 20190118 1
Epstein-Barr Virus latent membrane protein-1 (LMP1) interacts with the SUMO-conjugating enzyme Ubc9, which induces protein sumoylation and may contribute to LMP1-mediated oncogenesis. After analyzing human lymphoma tissues and EBV-positive cell lines, we now document a strong correlation between LMP1 and sumo-1/2/3 or SUMO-1/2/3 levels, and show that LMP1-induced sumo expression requires the activation of NF-κB signaling through CTAR1 and CTAR2. Together, these results point to a second mechanis ...[more]