Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin.
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ABSTRACT:
SUBMITTER: Whigham CA
PROVIDER: S-EPMC6338784 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
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Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin.
Whigham Carole-Anne CA MacDonald Teresa M TM Walker Susan P SP Pritchard Natasha N Hannan Natalie J NJ Cannon Ping P Nguyen Tuong Vi TV Hastie Roxanne R Tong Stephen S Kaitu'u-Lino Tu'uhevaha J TJ
Scientific reports 20190118 1
Preeclampsia is a pregnancy complication associated with elevated placental secretion of anti-angiogenic factors, maternal endothelial dysfunction and organ injury. GATA2 is a transcription factor expressed in the endothelium which regulates vascular homeostasis by controlling transcription of genes and microRNAs, including endothelial miR126. We assessed GATA2 and miR126 in preeclampsia. Whole blood circulating GATA2 mRNA and miR126 expression were significantly decreased in women with establis ...[more]
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Project description:Preeclampsia (PE) is a common pregnancy disorder, and it complicates 5~7% of all pregnancies. At present, termination of pregnancy is the only curative strategy for PE. To explore a potential target for PE treatment, we collected placental tissue samples from patients with preeclampsia (PE) and normal pregnant women (N), and performed high-throughput RNA sequencing. We found that FOXP2 was significantly downregulated in placental samples of patients with PE compared with the controls.
2024-11-06 | GSE279757 | GEO