Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin.

ABSTRACT: Preeclampsia is a pregnancy complication associated with elevated placental secretion of anti-angiogenic factors, maternal endothelial dysfunction and organ injury. GATA2 is a transcription factor expressed in the endothelium which regulates vascular homeostasis by controlling transcription of genes and microRNAs, including endothelial miR126. We assessed GATA2 and miR126 in preeclampsia. Whole blood circulating GATA2 mRNA and miR126 expression were significantly decreased in women with established early-onset preeclampsia compared to gestation-matched controls (p?=?0.002, p?

SUBMITTER: Whigham CA 

PROVIDER: S-EPMC6338784 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature