Ontology highlight
ABSTRACT:
SUBMITTER: Whigham CA
PROVIDER: S-EPMC6338784 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20190118 1
Preeclampsia is a pregnancy complication associated with elevated placental secretion of anti-angiogenic factors, maternal endothelial dysfunction and organ injury. GATA2 is a transcription factor expressed in the endothelium which regulates vascular homeostasis by controlling transcription of genes and microRNAs, including endothelial miR126. We assessed GATA2 and miR126 in preeclampsia. Whole blood circulating GATA2 mRNA and miR126 expression were significantly decreased in women with establis ...[more]