Ontology highlight
ABSTRACT:
SUBMITTER: Nagano T
PROVIDER: S-EPMC6339261 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nagano Taiki T Yamao Shunsuke S Terachi Anju A Yarimizu Hidetora H Itoh Haruki H Katasho Ryoko R Kawai Kosuke K Nakashima Akio A Iwasaki Tetsushi T Kikkawa Ushio U Kamada Shinji S
Life science alliance 20190118 1
d-amino acid oxidase (DAO) is a flavin adenine dinucleotide (FAD)-dependent oxidase metabolizing neutral and polar d-amino acids. Unlike l-amino acids, the amounts of d-amino acids in mammalian tissues are extremely low, and therefore, little has been investigated regarding the physiological role of DAO. We have recently identified <i>DAO</i> to be up-regulated in cellular senescence, a permanent cell cycle arrest induced by various stresses, such as persistent DNA damage and oxidative stress. B ...[more]