Correlation between Interleukin-17 gene polymorphism and osteoarthritis susceptibility in Han Chinese population.

ABSTRACT: BACKGROUND:Interleukin-17 (IL-17), a pleiotropic cytokine, plays a significant role in the inflammatory diseases. By a pilot study with small population, IL-17 polymorphisms (IL-17A rs2275913 and IL-17F rs763780) showed a more potential risk factor in knee osteoarthritis (OA) in our recruited subjects. In the current study, the association between IL-17A rs2275913 and IL-17F rs763780and the risk of OA in a Chinese population is studied. METHODS:The IL-17A rs2275913 and IL-17F rs763780 polymorphisms were determined in 594 knee OA cases and 576 healthy controls, using polymerase chain reaction-restriction fragment length polymorphism assay. The relationship between genotype distribution and disease risk, as well as OA severity was analyzed by Chi-square test and multivariate logistic regression. RESULTS:The experimental results indicated that the polymorphism in IL-17 gene rs2275913 site were related to knee OA risk after the adjustment of BMI, sex, age, smoking and drinking status (AA vs. GG: odds ratio (OR), 1.411; 95% confidence interval (CI), 1.021-1.950; P?=?0.040; A allele vs. G allele: OR, 1.192; P?=?0.037; 95% CI, 1.012-1.404;). Similarly, subjects who are bearing the rs763780 variant genotypes (TC and CC) and C allele also had a higher susceptibility to knee OA compared with those who are bearing the TT genotype (TC vs. TT, OR: 1.312; P?=?0.039; 95% CI: 1.017-1.692; CC vs. TT, OR: 2.812, P?=?0.006, 95% CI: 1.338-5.909; C allele Vs. T allele, OR:1.413, P?=?0.002, 95% CI:1.141-1.751). In the meantime, one high-risk haplotypes, AC (OR was 7.22, P?

SUBMITTER: Bai Y 

PROVIDER: S-EPMC6339292 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature