Ontology highlight
ABSTRACT:
SUBMITTER: Nemec CM
PROVIDER: S-EPMC6339578 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nemec Corey M CM Singh Amit K AK Ali Asfa A Tseng Sandra C SC Syal Kirtimaan K Ringelberg Kennedy J KJ Ho Yi-Hsuan YH Hintermair Corinna C Ahmad Mohammad Faiz MF Kar Rajesh Kumar RK Gasch Audrey P AP Akhtar Md Sohail MS Eick Dirk D Ansari Aseem Z AZ
Nature chemical biology 20181231 2
Phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) governs stage-specific interactions with different cellular machines. The CTD consists of Y<sub>1</sub>S<sub>2</sub>P<sub>3</sub>T<sub>4</sub>S<sub>5</sub>P<sub>6</sub>S<sub>7</sub> heptad repeats and sequential phosphorylations of Ser7, Ser5 and Ser2 occur universally at Pol II-transcribed genes. Phosphorylation of Thr4, however, appears to selectively modulate transcription of specific cl ...[more]