Ontology highlight
ABSTRACT:
SUBMITTER: Huber VJ
PROVIDER: S-EPMC6339703 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Huber Vincent J VJ Igarashi Hironaka H Ueki Satoshi S Terumitsu-Tsujita Mika M Nito Chikako C Ohno Ken K Suzuki Yuji Y Itoh Kosuke K Kwee Ingrid L IL Nakada Tsutomu T
Contrast media & molecular imaging 20190106
Matrix metalloproteinases (MMPs) damage the neurovascular unit, promote the blood-brain barrier (BBB) disruption following ischemic stroke, and play essential roles in hemorrhagic transformation (HT), which is one of the most severe side effects of thrombolytic therapy. However, no biomarkers have presently been identified that can be used to track changes in the distribution of MMPs in the brain. Here, we developed a new <sup>19</sup>F-molecular ligand, TGF-019, for visualizing the distribution ...[more]