Ontology highlight
ABSTRACT:
SUBMITTER: Codreanu SG
PROVIDER: S-EPMC6339813 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Codreanu Simona G SG Hoeksema Megan D MD Slebos Robbert J C RJC Zimmerman Lisa J LJ Rahman S M Jamshedur SMJ Li Ming M Chen Sheau-Chiann SC Chen Heidi H Eisenberg Rosana R Liebler Daniel C DC Massion Pierre P PP
Journal of proteome research 20170808 9
We hypothesized that distinct protein expression features of benign and malignant pulmonary nodules may reveal novel candidate biomarkers for the early detection of lung cancer. We performed proteome profiling by liquid chromatography-tandem mass spectrometry to characterize 34 resected benign lung nodules, 24 untreated lung adenocarcinomas (ADCs), and biopsies of bronchial epithelium. Group comparisons identified 65 proteins that differentiate nodules from ADCs and normal bronchial epithelium a ...[more]